Revealing stromal and lymphoid sources of <i>Col3a1</i>-expression during inflammation using a novel reporter mouse

Abstract One of the earliest signs dysregulation homeostatic process fibrosis, associated with pathology in chronic conditions such as rheumatoid arthritis, is overexpression collagen type III (COL-3). Critically, there still relatively little known regarding identity cell types expressing gene encoding COL-3 (Col3a1). Identifying and characterizing Col3a1-expressing cells during development fibrosis could reveal new targets for diagnosis treatment fibrosis-related pathologies. As such, a reporter mouse concomitantly Col3a1 mKate-2, fluorescent protein, was generated. Using models footpad inflammation, we demonstrated its effectiveness tool to measure expression repair provided an initial characterization some stromal immune responsible expression.